Etiology, methods of prevention and treatment of infectious bovine keratoconjunctivitis

Abstract

Infectious bovine keratoconjunctivitis (IBK) is caused by Moraxella bovis bacteria. The methods for isolating pathogens were developed. Culture media for their isolation were developed. The frequency (percentage of cases) of isolation of these bacteria was determined. To convert the preliminary diagnosis into a reliable one, a reproduction of this disease was carried out. Great importance in reducing damage from Moraxella bovis induced keratoconjunctivitis is based on preventive and therapeutic measures. Therefore, based on the results of the study of the prevalence of this disease, the goal and subsequent tasks were set which were to develop and test a vaccine for the prevention and treatment regimens for IBK. The immunizing doses of the developed vaccine were determined. Its harmlessness and lack of toxicity were determined. The immunizing dose and treatment regimens for various sex and age groups were developed. Efficacy test was conducted. The greatest activity was recorded in the group of heifers, and then among calves and cows. Treatment regimens were proposed. Two treatment regimens were compared: the use of the Azitrovet drug and a new combination of Azithromycin and Tetracycline; then the most effective one was selected in terms of various indices. When studying the therapeutic effectiveness of the vaccine, its high effectiveness was revealed. The increased activity of the compositional form of therapy is explained by the potentiating interaction of its components and the preventive generation of populations of drug-resistant forms of pathogens (Moraxella). Azithromycin in combination with tetracycline (96%) compared to Azitrovet (92%) has the greatest therapeutic efficacy against infectious keratoconjunctivitis. The conclusions arising from the conducted research were made; on their basis the proposals and veterinary and sanitary measures to combat IBK were formulated.