Influence of drugs of various groups on biofilm formation by S. enteriditis 182

Abstract

Currently, it is believed that most of the microorganisms responsible for the occurrence of an infectious disease exist in the form of biofilms. Biofilms are complex microbial communities where cells have greater resistance to aggressive environmental factors than cells that live separately. Biofilms are also more resistant to antibiotics. For this reason, search is conducted for substances with antibiotic properties of natural origin. This paper discusses the research findings on the influence of microbiological preparations and preparations based on enzymes of bacterial origin (produced by OOO PO “Sibbiofarm”, Russia) on the process of biofilm formation of opportunistic microflora in vitro. The bacteria S. enteritidis 182 was used as the research target. The research findings show that Fercon P reduces the ability to form biofilms by 20%, Fercon PN - by 11%, Fercon DN - by 8%, Fercon D - by 4%. The effect on the ability of Salmonella enteritidis 182 to form biofilm after the use of enzyme preparations was as follows: Bactofit reduced biofilm formation by 33%, Yarocide - by 36%, Amylosubtilin - by 38%, and Protosubtilin - by 50%. The research findings on the effect of drugs of different groups on biofilm formation showed that the greatest effect was revealed when using the drug Ferkon P, there was decrease by 20%, while the use of the enzyme preparation Protosubtilin reduced biofilm formation in S. enteritidis 182 by 50%. These data indicate the possibility of using enzyme preparations and disinfectants as anti-biofilm agents with the possibility of creating complex drugs for the treatment of infectious animal diseases.