Dynamics of weight indices of internal organs under conditions of implantation of plates coated with titanium and hafnium nitrides

Abstract

An urgent problem of veterinary surgery - the development of biocompatible implantation materials resistant to complications and rejection is discussed. This study is devoted to studying the effect of titanium and hafnium nitride (TiN + HfN) coatings with high-frequency plasma treatment on the rat body during subcutaneous implantation of metal plates. The research goal is a comparative analysis of the relative weight of internal organs in experimental rats during implantation of plates coated with titanium and hafnium nitrides with high-frequency plasma treatment. The experimental study was conducted on 20 male rats divided into 4 groups: steel 12X18H9T + (TiN + HfN), steel 12X18H9T uncoated, titanium BT6 and titanium BT6 + (TiN + HfN). The experiment lasted for 30 and 60 days. The implantation was performed under general anesthesia in compliance with the rules of asepsis. The clinical parameters and the condition of the tissues in the wound area, the dynamics of body weight and temperature were evaluated. A macromorphological study was performed to determine the weight of the liver, heart, lungs and kidneys. The recorded indices may be related to the manifestation of the toxic effects of metals on the body of the experimental animal. The data obtained indicate the effect of coatings and plasma treatment on the biocompatibility of implantation materials and require further study to optimize their use in veterinary surgery.