Study of local irritation effect of the antimycotic agent “TK-46”

Abstract

Dermatophyte infections caused by microscopic fungi of the genera Trichophyton spp. and Microsporum spp. are often found in farm, domestic and wild animals. Various antimycotic drugs are used to control dermatophytosis but not all medicines meet safety requirements. In this regard, today, an urgent issue is the search for new effective and safe medicines. The irritating effect of a new antimycotic agent against dermatophytes under the code “TK-46” is discussed. The evaluation of the irritation effect of the drug on the skin was made by applying it once to a pre-prepared area of the skin of white rats in concentrations of 1% and 10%. During the experiment, significant changes in the skin condition of the experimental animals receiving the drug were not detected. Slight redness of the skin of laboratory animals when applying the drug at a concentration of 1% took place within 1 hour. The severity of the irritation effect was 1.5 ± 0.07 points. When applying the drug at a concentration of 10%, erythema completely disappeared within 1.5 hours. In this case, the severity of the irritation effect of the drug was 2.0 ± 0.12 points. The effect of the “TK-46” agent on the mucous membranes was studied on rabbits with a live weight from 2.5 kg to 3.0 kg; 2 drops of the drug were instilled into the conjunctival sac of the right eye. It was found that the drug in the studied concentrations had a weakly irritating effect on the skin and a moderately irritating effect on the mucous membrane of the animals’ eyes.