Evaluation of therapeutic efficacy of the antimycotic agent TK-46

Abstract

Dermatophytosis cases are widespread almost all over the world and they occupy a leading place among animal skin pathologies of infectious etiology. Their high contagiousness, duration and complexity of treatment lead to significant economic damage. In this regard, the urgency of developing effective and safe medicines for the treatment of dermatophytosis in animals is obvious. Comparative evaluation of the therapeutic efficacy of various forms and concentrations of the developed antimycotic agent under the code TK-46 was carried out. It was found that the drug in the form of a 1% solution had the greatest activity against the dermatophyte Microsporum canis. The therapeutic efficacy of this formulation in experimental microsporia of guinea pigs was 96.2%. The hair coat in this group of animals recovered faster, the glow of hairs under Wood’s lamp was absent. The results of hair inoculation and microscopy were negative. Hematological indices were within the physiological range, and body temperature, pulse rate and respiratory rate had no significant difference compared to the intact group. The remaining formulations of the drug were less effective, while the efficacy of the 1% ointment form was 73.1%, and the 0.5% solution was 65.4%. In these groups of animals, the infectious process was more intense, and the recovery time of the hair coat increased.