Safety evaluation of a feed supplement based on selenium and cobalt aspartate nanoparticles for ruminants

Abstract

The experimental data on identifying the acute toxicity of the feed supplement which contains nanoparticles of selenium and cobalt aspartate on white non-linear mice and young cattle are discussed. The administration of the tested feed supplement to non-linear white mice, both males and females, at doses of 1000, 2500, 4500 and 5500 mg kg did not lead to the death of the animals. When administering supplements in doses of 1000 and 2500 mg per kg of body weight, no symptoms of intoxication were observed. At the same time, in non-linear white mice, after administration of the supplement in doses of 4000 and 5500 mg kg, depression was observed, and the animals were lying most of the time, they were hypodynamic, and had impaired hair condition. These symptoms were relieved within 1-2 hours after administration. Subsequently, the mice did not differ from the control ones. It was not possible to determine the average lethal dose for the feed supplement since the maximum possible doses for intragastric administration did not lead to the death of a single animal. According to the generally accepted hygienic classification of the State Standard GOST 12.1.007-76, feed supplement belong to hazard class 4 (low-hazard substances). As shown by the research findings, in calves of the first and second trial groups, in 30 days from the start of the experiment, no significant differences were found between the results obtained and the initial values. It may be concluded that giving the feed supplements does not have a negative effect on peripheral blood. The feed supplement is well tolerated.